Hydroxyl Ion Addition to One-Electron Oxidized Thymine: Unimolecular Interconversion of C5 to C6 OH-Adducts

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Hydroxyl ion addition to one-electron oxidized thymine: unimolecular interconversion of C5 to C6 OH-adducts.

In this work, addition of OH(-) to one-electron oxidized thymidine (dThd) and thymine nucleotides in basic aqueous glasses is investigated. At pHs ca. 9-10 where the thymine base is largely deprotonated at N3, one-electron oxidation of the thymine base by Cl(2)(•-) at ca. 155 K results in formation of a neutral thyminyl radical, T(-H)·. Assignment to T(-H)· is confirmed by employing (15)N subst...

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Lesions of the nerve produce weakness of flexion at the elbow and weakness of supination. The biceps is an important supinator. There is sensory loss on the lateral side of the forearm. The brachialis muscle receives innervation from both the musculocutaneous nerve and the radial nerve. [7, 8] One study found that the musculocutaneous nerve contributes to 42% of the muscle power that flexes the...

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Musculocutaneous Nerve Lesion (C5-C6)

Lesions of the nerve produce weakness of flexion at the elbow and weakness of supination. The biceps is an important supinator. There is sensory loss on the lateral side of the forearm. The brachialis muscle receives innervation from both the musculocutaneous nerve and the radial nerve. [7] [8] One study found that the musculocutaneous nerve contributes to 42% of the muscle power that flexes th...

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ژورنال

عنوان ژورنال: Journal of the American Chemical Society

سال: 2013

ISSN: 0002-7863,1520-5126

DOI: 10.1021/ja310650n